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doi: 10.1007/s10620-009-0765-9

In 1998, he starred as what is arguably his most iconic role, Jeffrey "The Dude" Lebowski, in the Coen brothers' noir comedy The Big Lebowski

One study successfully increased lubricin (lubricating protein) concentration in superficial zone chondrocytes

These patterns could affect how their bodies handle stress, detoxification, and even behavior

This processing happens in two distinct stages, known as Phase I and Phase II detoxification

doi: 10.1016/S0168-3659(98)00182-5
