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It has garnered attention for its potential antiaging properties, primarily through its influence on telomere elongation and telomerase activity, which are crucial factors in cellular aging and longevity

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These clinical deficiencies emphasise a need for novel, genomically guided therapies that are based on a greater understanding of the molecular and cellular mechanisms that underlie NF1-associated cNFs, and at the time of writing, nine interventional clinical trials were identified for cNFs (Table 1)

DNA methylation was one of the first identified and the most widely studied epigenetic alteration [37]

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In response, the brain activates the microglia which undergo morphological changes, that is, polarization to the M2 phenotype, and begin producing various inflammatory mediators, including TNF- , IL-1, and IL-6