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Polyphenols, on the other hand, exert their effects by activating antioxidant and anti-inflammatory pathways, such as Nrf2 signaling, and modulating kinases like ERK and CREB, which are crucial for synaptic plasticity and cognitive function

Data availability The authors declare that the data supporting the findings of this study are available within the paper and its Electronic Supplementary Information files

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Holmgren A

Brain Res 2015 Nov 2;1625:97-101 13

Characterization of a cell line derived from zebrafish (Brachydanio rerio) embryos

IGF-1 in the CNS IGF-1 can cross the blood brain barrier (BBB) and enter CSF, and perform a number of important functions of the CNS, including neurogenesis and neuroprotection, through autocrine/paracrine or endocrine effects