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The presence of these systemic effects appears to worsen a patients prognosis 114
5 METHODS TO RESTORE NAD+ The evidence demonstrates that the biology behind NAD+ decline is complex

This is consistent with microarray studies that demonstrated significantly high expression of TGFBI in methotrexate, cisplatin, doxorubicin, vincristine, topotecan and paclitaxel-resistant ovarian cancer cell lines and reconciled those findings to changes in ECM remodeling in response to drug treatment [47]

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Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, et al

doi: 10.1186/s12967-023-04559-9 230 YinL.TuH.ZhuY.QianJ.YangY.WeiC.et al