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Researchers designing studies should carefully consider the evidence gap

As opposite, in the extracellular medium, a detectable decrease in the concentrations of these proteins would be less likely due to the absence of the cellular machinery for protein degradation

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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing