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[DOI] [PubMed] [Google Scholar] 117.Kasherman Y., Sturup S., Gibson D

At week 6, 10 mg/kg CX group showed vacuolar degeneration, 4 and 6 mg/kg CX groups had inflammation, and 8 mg/kg CX group maintained optimal improvement

Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis

19 , 20 Within the fibrotic microenvironment, endometrial stromal cells also exhibit elevated expression of -smooth muscle actin (-SMA), further enhancing type I collagen accumulation and contributing to increased tissue stiffness

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However, this analysis did not specifically address CRC-associated metabolic adaptations or resistance mechanisms