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This could be due to lack of either glutathione reductase or NADPH
In cases of kidney injury, we observed an increase in hexokinase activity as well as pyruvate content in renal tissues (Figure 1G), which, combined with our previous and current findings, suggests that the increased activity of the glycolytic pathway plays a significant role in the increased production of MG during tissue injury

Biomed Res Int 2016:3423685

The beauty of GHK-CU is that the peptide chelates copper, preventing free ion toxicity while ensuring cellular delivery

Some are in the methylation pathway and others are in the GSH production pathway

However, the large size of the therapeutic molecule restricts its access to tumour cells, particularly in central regions of solid tumours (Russell et al, 1992)
