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Most evidence remains preclinical, with limited controlled human research currently available

More recently, pure ergotamine has been used for the treatment of migraine headaches

When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

But does it work, or is it just another overhyped trend

Although all the organ systems age progressively with time, the female reproductive system stands out

For best results, start with 1/4 dose and work up to the full dose over the course of 4 to 10 days