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These compounds play an important role in preventing oxidative stress caused by the endogenous formation of hydrogen peroxide (H 2 O 2 ) by aerobic metabolism

C3G not only attenuates cellular and tissue oxidative stress but also reduces Fe 2+ levels, inhibits nuclear receptor coactivator 4 (NCOA4) expression, and concurrently regulates transferrin receptor protein 1 (TfR1) downregulation and ferritin heavy chain 1 (FTH1) upregulation

doi: 10.1152/physrev.1999.79.1.S145

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