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Second, elevated antioxidant metabolites such as arginine and citrulline paralleled skin lightening effects, consistent with oxidative stress mechanisms in melasma [27]

Furthermore, Nrf2/HO-1 interacts with the NF-KB and JAK-STAT pathways in various contexts: Nrf2/HO-1 can reduce NF-KB phosphorylation and thereby dampen inflammation, whereas proinflammatory cytokines such as TNF- and IL-6, released following NF-KB activation, upregulate HO-1 in a feedback loop (125, 129)

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Results Characterization of NAC-SNPs and NAC-SNPs/pALG beads Morphological analysis of NAC-SNPs through TEM and SEM revealed uniform spherical nanoparticles with diameters ranging from 110 to 140 nm (Fig