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However, if the mutation arises on a macrohaplogroup M mtDNA and this mtDNA resides in high altitude, then this same variant is associated with maximum complex I activity and adaptation to high altitude (Ji et al

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Laski, "String of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis", Genetics 137: 1039-1048 (1994)

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