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In another study, Cupriavidus necator JMP134 was reported to degrade 2,4-D by stepwise conversion from 2,4-dichlorophenol (2,4-DCP) by 2,4-D dioxygenase encoded by TfdA gene, and 2,4-DCP was further degraded to -ketoadipate by 2,4-DCP hydroxylase encoded by TfdB , chlorocatechol dioxygenase encoded by TfdC , chloromuconate cycloisomerase encoded by TfdD , dienelactone hydrolase encoded by TfdE , and chloromaleylacetate reductase encoded by TfdF gene

Sohal RS, Farmer KJ, Allen RG, Ragland SS, 1984

3b, Table S6)

While the analogy isn't perfect, it captures the essence of why researchers often prefer localized protocols for joint-specific studies

When your mucosal barrier is compromised, those tight junctions between cells in the intestinal walls open up, leading to small gaps where bacteria and other toxins can move freely

Varga V, Jenei Zs, Janky R, Saransaari P, Oja SS