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Different mouse models of neurodegeneration, such as the CK-p25, Tau P301S have demonstrated elevated C1q levels 19,49 , and previous data have shown that GENUS reduced C1q signal in both CK-p25 and P301S mice by GENUS 19

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We found that while HGF or c-MET inhibition alone had variable effects on cancer migration, stemness and EMT, simultaneous inhibition of both the ligand and receptor (Hi + Ci) consistently reduced cancer cell migration/invasion into collagenous matrices, stem cell marker expression and EMT (Fig