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In ovarian cancer (OC), although nicotine activates multiple signaling pathways via 5-nAChR, different types of ovarian cancer cells show different responses

Several large clinical cohort studies have shown that TMAO and its precursors are independently associated with prevalent CVD and incident major adverse cardiac events (MACE) [24, 3033]

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10.1016/j.carbpol.2014.01.073 67 ShaoP.LiuJ.ChenX.FangZ.SunP

This may account for the difference in mortality between our study and Zhang et al