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Unfortunately, results derived from large-scale randomised clinical trials have been rather disappointing

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Curr Med Chem 21:15571565 Tan DX, Hardeland R, Back K, Manchester LC, Alatorre-Jimenez MA, Reiter RJ (2016) On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species

Lancet Oncol 3(8):461469 Hecht SS (2012) Lung carcinogenesis by tobacco smoke

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Similarly, a yeast strain lacking a functional copy of the GSH1 gene was unable to grow on minimal media