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Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity

Besides regulating uptake and distribution of essential heavy metals, Nramps have also been found to be involved in the transport of non-essential heavy metals

Interestingly, this has not discouraged multiple research groups testing cysteine prodrugs, such as N-acetylcysteine (NAC), as supplements to increase GSH levels

189 ALOX-dependent ferroptosis also plays a role in lung infection

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the highest cell viability, 87%, was identified when cells were pretreated with 2 mM ALA