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For example, the upregulation of the Nrf2 pathway by lipoic acid in cultured hepatocytes and in the liver of obese or diabetic rats prevented lipid overload-induced steatosis (35) and cell death (36)

While the interaction is complex, studies have shown that ACEIs and ARBs can decrease serum TMAO levels and increase urinary excretion of TMAO

However, XO-derived RS production is increased in tissues affected by certain diseases, including atherosclerosis (Nasi et al., 2021), rheumatoid arthritis (Hanachi et al., 2009), or Dupuytrens contracture (Murrell and Hooper, 1992)

Such energy deficits can exacerbate pain sensitivity, and therapeutic strategies targeting mitochondrial function may offer new avenues protecting affected individuals against the pain chronification [67]

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KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis