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Although tirzepatide has no established direct mechanism for causing insomnia, several indirect pathways may explain why some patients experience sleep disturbances during treatment

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Although in cognitively healthy individuals differences in BBB uptake have been observed with APOE genotypes as early as in individuals in their 30s (Yassine et al., 2017) in mice older ages may be required for such disturbances to occur (Alata et al., 2015)

(2020, September 14)

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