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Description
Depletion of GSH due to intensified oxidative stress or the action of inhibitors significantly reduces the ability of GPX4 to counteract lipid peroxidation, leading to increased lipid peroxides and subsequent ferroptosis (151)
Petkova, S
However, studies into their potential for treating various other CNS-related diseases are actively ongoing
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Antioxidants & Redox Signal
Ann Pharmacother 2009;43(2):304315
