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These effects were associated with increased F-actin formation and activation of focal adhesion kinase (FAK) and paxillin phosphorylation, signaling events central to cell attachment and cytoskeletal remodeling during tissue repair processes [4]

As observed in H&E staining, FA injection induced severe tubular damage, indicated by detachment of tubular cells, dilation of tubules, swelling of tubular cells, degeneration of epithelial cells, and interstitial inflammatory cells infiltration

The past three decades research in the area of angiogenesis also invented a series of novel and effective anti-angiogenic agents targeting the VEGF signaling axis

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The Rotterdam Study

Interestingly, at the age of 47 years P20 developed extensive surgical emphysema within the subcutaneous tissues of her face and computed tomography (CT) scans of the sinuses revealed a defect of the left nasal cartilages anteriorly allowing air to track into the soft tissues