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We chose to focus on MRS profiling of the ACC and SMA because both have been previously implicated in the neural circuitry of compulsivity (see Introduction)

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Several SAM-dependent radical enzymes exist in the body, and the SAM radical enzyme family can form characteristic [4Fe-4S] clusters

Specifically, we addressed the issues of different pathways from passive transcytosis, intranasal administration, ligands conjugation for brain targeting, membrane coating for brain targeting, to stimuli-mediated BBB disruption

1b, c), suggesting that WH2_1 might constitute the G-actin binding domain