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Both are well studied, unanimously accepted among researchers, and present in all ME/CFS patients (at least if diagnosed according to the now internationally accepted Canadian Consensus Criteria) (Carruthers et al., 2003)

doi: 10.1186/1742-2094-11-81

The liver is a key target organ for methylation reactions where SAM is the methyl donor (Figure 1(a)) and participates in posttranslational protein modifications, DNA and histone tail methylation, as well as many metabolic pathways such as creatine synthesis [1315], carnitine synthesis [16, 17], and endogenous phosphocholine synthesis [18]

Experimental literature has also investigated VEGF and VEGFR2 signaling, growth hormone receptor expression in tendon fibroblasts, neurotransmitter modulation, and neuroprotective pathways involving the dopaminergic and serotonergic systems
