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doi: 10.4088/JCP.24m15272

Knockout and inhibition of Ape1: roles of Ape1 in base excision DNA repair and modulation of gene expression

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In vivo experiments showed the peptide rapidly restoring blood flow through collateral vessel activation in models of venous occlusion, an effect closely linked to the NO system and reduction of free radical formation

Cheeran MC, Lokensgard JR, Schleiss MR

Given that melatonin is a small amphiphilic molecule (61), its intracellular actions do not necessarily require engagement of surface receptors