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2018 Moreover, 8-OHD markedly quenched reactive oxygen species (ROS) and activated NF-E2-related factor 2 (Nrf2) so as to upregulate expression of Phase II enzymes, including heme oxygenase (HO)-1, NADH quinone dehydrogenase 1 (NQO1), and the modifier subunit of glutamate cysteine ligase (GCLM)

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However, the increase in ROSs induced by drugs seems to play a different role compared to the role of ROS originally generated in malignant tumors