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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

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Early studies with the bacterial isolate Acinetobacter calcoaceticus have reported a link between BB and TMA production (42)

Similarly, exercise elevates metabolism, causing an increase in the use of oxygen and eventually resulting in oxidative stress 16 , 17

Kline CE, Chasens ER, Bizhanova Z, Sereika SM, Buysse DJ, Imes CC, Kariuki JK, Mendez DD, Cajita MI, Rathbun SL, Burke LE