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glutathione for oxidative stress Hypothetical scheme showing some glutathione-linked responses in The Roles of Glutathione and
Description
Often referred to as the bodys master antioxidant , glutathione is a remarkably powerful molecule composed of three amino acids glutamine, glycine, and cysteine

A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme
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Glutathione works to maintain homeostasis and ease oxidative stress by protecting and repairing cells, proteins, and DNA (Wu et al., 2004)

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The decrease in GSH in the endothelium induces ROS levels, decreases the activity of eNOS, and increases organ fibrosis [138]
