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2 Methods For this narrative review, studies investigating the application of engineered bacteria in the treatment of metabolic, cardiovascular and cerebrovascular diseases were searched in the major databases of scientific literature (PubMed, ScienceDirect, Scopus) from those published between 1999 and 2025, using the keywords: gut microbiota, engineered bacteria, probiotics, cardiovascular diseases, coronary artery disease, hypertension, obesity, diabetes mellitus, Parkinson's disease, Alzheimer's disease, gut-heart axis, gut-brain axis, homocystinuria

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