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[DOI] [PMC free article] [PubMed] [Google Scholar] Beklemisheva AA, Fang Y, Feng J, Ma X, Dai W, Chiao JW

MARKET--MARCH 2000 Increases tissue insulin sensitivity decreased insulin resistance decreased insulinemia reduced fasting and postprandial hyperglycemia in Type II diabetics (non-insulin dependent diabetics, NIDDM) Rosiglitazone* (Avandia)-- FDA approved for management of Type II diabetes ---Concern about this agent responsible for excessive number of heart attack and congestive heart failure (2/2010) Approval as monotherapy or in combination with metformin (Glucophage) might be used with insulin or a sulfonylurea Apparently as effective does troglitazone (Rezulin) in controlling blood glucose without liver toxicity Long-term safety/benefits of rosiglitazone (Avandia) in patients with Type II diabetes: yet to be determined

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Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity

However, the impact of this improved bioenergetic and anti-inflammatory profile in PBMC, driven by NR, on MASLD was not explored, as these studies were not focused on MASLD, and liver function was assessed only through routine laboratory tests as part of the safety protocols, with no significant changes reported [99, 104]