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For instance, the glioma cell death was increased by combining chloroquine (CQ) with AKT-1/2 and PI-103, two inhibitors of PI3K/mTOR/AKT [202, 203]

Janku F, Huang HJ, Fujii T, Shelton DN, Madwani K, Fu S, Tsimberidou AM, Piha-Paul SA, Wheler JJ, Zinner RG, Naing A, Hong DS, Karp DD, Cabrilo G, Kopetz ES , Subbiah V, Luthra R, Kee BK, Eng C, Morris VK, Karlin-Neumann GA, Meric-Bernstam F

Future studies should aim to clarify its mechanisms of action, optimal dosing regimens, and long-term safety profiles, thereby paving the way for its integration into comprehensive MASLD treatment protocols

15 Age-matched male mice (six to eight weeks old, weighting 2025 g) were selected for further experiments

& Wittmann, C

Neutralizing GM-CSF or depleting eosinophils significantly reduces colitis severity, directly demonstrating eosinophil pathogenicity in chronic adaptive immune-driven colitis (107)