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Archived from the original on August 11, 2022

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The selection criteria complied with age 45 years, body mass index (BMI) in the range of 2535 kg/m 2 , and diagnosis of KOA according to the clinical classification of KOA [22]

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Opioids, such as heroin, primarily target the brains reward system and induce oxidative stress, neuroinflammation, and cerebrovascular complications

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