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Hydroxy- sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9

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2.4 Methodological Quality Appraisal To investigate the methodological quality of the evaluated studies, we used the Cochrane risk of bias tool for randomized trials (version 2, RoB 2, London, United Kingdom), which consists of six main items for evaluating study quality: the randomization process, intervention adherence, missing outcome data, outcome measurement, selective reporting, and the overall risk of bias (Sterne et al., 2019)