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doi: 10.1016/j.sleep.2023.03.011 196 ZhouL.LiG.ZhangY.ZhangM.ChenZ.ZhangL.et al
Anal Chem 87:706715

For example, DSIP causes drowsiness, increases sleep time by 59% compared to placebo, and shortens the time to fall asleep

This is due to a favorable electrostatic attraction that induces tight junction opening, resulting in enhanced paracellular transport of ions, macromolecules, and hydrophilic drugs across cell barriers, and importantly, improves the BBB penetration of drug-loaded nanoparticles via adsorptive-mediated endocytosis (Roney et al., 2005

This appetite-regulating action is the core of its metabolic-research appeal

Importantly, genetic variation is a modifier of glutathione status and influences response to nutritional factors that impact glutathione levels
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