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Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimers disease

Astrocytes are intimately interconnected with all cells of the nervous tissue (the brain active milieu 15 ), with numerous feedback and feedforward signals contributing to the integration of a broad variety of cellular functions in the CNS

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Zhang MF, Chen RJ, Tang W, Zhang HF

ALS is a leucine-rich glycoprotein that forms high-affinity ternary complexes with IGFBP-3 or IGFBP-5 when they are occupied by either IGF-1 or IGF-2

[DOI] [PubMed] [Google Scholar] 137.Duarte E.C.B., da Silva M.S.L., Gomez M.V., Gomez R.S

doi: 10.1016/j.bcp.2008.09.036 126 RothhammerVMascanfroniIDBunseLTakenakaMCKenisonJEMayoLet al
