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Furthermore, Sema4D/PlexinB1-driven GR nuclear translocation requires an intact NLS1 in GR [34], implicating the importin/Ran system in the process

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10.1038/nm.3324

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

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