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Identification of two gene clusters and a transcriptional regulator required for Pseudomonas aeruginosa glycine betaine catabolism

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In animal models, 8 months of KD feeding in middle-aged mice (8.5 months old) improved cognition and ameliorated A and tau pathology (104)

[163]) might be related to osmotic stress rather than pathological modification of the eye lens and that chronic aberration of osmotic pressure causes net loss of carnitine which can lead to triggering of cataracts

Further experiments confirmed that miR-499-5p targets SOX6 , a specific factor known to inhibit the expression of slow-twitch muscle genes, and miR-196-5p targets CALM1 , a key element in the cGMP-PKG and calcium signaling pathways

doi: 10.1146/annurev-micro-091014-104422 62 RossABZanggerAGuiraudSP