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Based on these studies that describe dysautonomic characteristics in patients with CVS, researchers have posited the hypothesis that this imbalance can cause patients to be more susceptible to producing an uncontrolled response to central emetic signals.27 During the inter-episodic phase of the disease, patients with CVS can present with accelerated gastric emptying in up to 59% of cases.30 In fact, accelerated gastric emptying can be an indirect marker of the underlying autonomic dysregulation in CVS

J Clin Endocrinol Metab 104(4):1171-80 2019 PMC6391355 Diabetes Prevention Program Research Group

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SGLT2 is expressed nearly exclusively in the apical membranes of epithelial cells of the proximal tubule of the kidney and has been shown to be responsible for approximately 90% of the renal glucose reabsorption (see Figure below)