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The classic liquid-state or random-collision model postulates that in the IMM there exists a bulk CoQ pool that is accessible to all the dehydrogenases that need to donate reducing equivalents to CoQ

The acetylation of histones was found to result in structural changes of the chromatin, which affect both DNA-protein and protein-protein interactions

In addition, it can modulate gut microbiota metabolism through the reduction of trimethylamine levels, acting in concert with the aforementioned effects (88)

Both can be effective in weight loss, but in head-to-head trials, tirzepatide has a slight edge over semaglutide