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The nonspecific immune system serves as the primary defense mechanism in crustaceans against invasive pathogens (Huang & Ren, 2020)
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Screening techniques for DPN, such as the 10-g monofilament and assessment of touch, vibration sense, and ankle reflexes, have limitations, primarily detecting advanced neuropathy and missing early stages, especially those associated with small fiber abnormalities and neuropathic pain [14, 17,18,19,20,21,22]
