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And, in extreme cases, surgical procedures

Guo M, Lu M, Chen K, Xu R, Xia Y, Liu X, et al

Furthermore, chitosan has demonstrated intrinsic anti-inflammatory properties by inhibiting tumor necrosis factor alfa (TNF-) secretion [34]

In vitro studies underpinning the design of the helix-B-derived peptides have documented that the pyroglutamate helix-B surface peptide (the structure corresponding to ARA-290) retains anti-apoptotic, cytoprotective activity, while lacking erythropoietic activity, and have attributed this cytoprotection to signalling through the EPO receptor (EPOR)/beta-common-receptor heterocomplex rather than the classical erythropoietic EPOR [1]

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