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PHD/EGLN are non-heme, iron and -KG-dependent dioxygenases that hydroxylate HIF-1, promoting its recognition by the von Hippel-Lindau (VHL) tumor suppressor protein and subsequent proteasomal degradation ( Figure 1 )

Thesis, McGill University (2013)

If so, remember to pull on the plunger a little to empty the medication from the existing needle to make sure you dont waste any