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Notably, EGFR inhibitor alleviated cochlear oxidative stress damage, further confirming EGFR/p-ERK as a pivotal node in the ROS-GSDMD positive feedback loop

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2008;7(9):275769 ( PMID: 18790744 )

The body attempts to overcome this limitation via the transsulfuration pathway in the liver, which converts the amino acid methionine into cysteine to ensure a steady supply for glutathione synthesis