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On the whole, these results support further studies on the role of bromelain in the treatment of tumors possibly representing a non-invasive treatment for people suffering from cancer

TPX2 promotes ferroptosis in LPS-induced C28/I2 chondrocytes via NF-B p65-mediated downregulation of GPX4 and SLC7A11

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Within endosome compartments, Fe 3+ is reduced to ferrous iron (Fe 2+ ) and released into a labile iron pool in the cytoplasm via the divalent metal transporter 1 (DMT1) ( Figure 5 )

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L-2-oxothiazolidine-4-carboxylic acid (OTC) treatment attenuated plasma and tissue P-selectin levels, suggesting that the upregulation of P-selectin in hyperhomocysteinemic mice is also regulated by redox mechanisms [61]