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As a result, the function of cells as a whole can change [11]

Benov, L.T., Beyer, W.F., Jr., Stevens, R.D., and Fridovich, I., Free Radical Biol

for instance, radiation therapy causes indirect damage to surrounding tissues, and chemotherapy results in vital organ toxicity and also causes drug resistance, whereas surgical interventions may sometimes precipitate tumor recurrence (Formenti and Demaria, 2009

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High% free Cu:Zinc ratio was a sufficiently significant finding in the overall data set to meet ROC criteria for biomarker status

The best practice is to use optimization as a starting point to directionally understand what products would be selected under a scenario with a ruthless adherence to a particular objective