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The barrier will still be an investigational new drug application in an FDA designated disease indication (of which for many of these peptide use cases, there isn't one)

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This approach is exemplified by Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase that diverts pyruvate away from lactate conversion and into mitochondria, and by Lonidamine, which suppresses glycolysis at its origin by inhibiting mitochondrially-bound hexokinase