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Specifically, depletion of mekk-3/Mitogen-activated protein kinase kinase 3 promotes a DR-like state that extends lifespan without affecting food intake, and longevity in this model requires nhr-49 ( nhr-49 RNAi significantly shortened the longevity of the eat-2 mutant (Heestand et al., 2013)

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Persistent hepatitis C viraemia without liver disease

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