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10.1378/chest.12-2664 [DOI] [PubMed] [Google Scholar] 80.Zinellu E, Zinellu A, Pau MC, Piras B, Fois AG, Mellino S, et al

Mechanism: Stimulates pulsatile GH release Increases IGF-1 without desensitizing pituitary Specifically reduces deep abdominal fat Benefits: Reduces visceral fat while maintaining or increasing lean mass Enhances insulin sensitivity and lipid metabolism Supports training capacity in overweight or aging populations Typical Dose: 2 mg subcutaneously once daily Best taken at night before bed IGF-1 LR3: Direct Muscle Growth Stimulation IGF-1 LR3 (Long Arg3) is a modified version of IGF-1 with an extended half-life, allowing for more consistent anabolic signaling

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