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Oral administration of allicin to mice lowered ROS production and prevented ROS-induced cardiac hypertrophy by inhibiting pro-inflammatory pathways like mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase 3 (GSK3) signaling pathways (20)

Oxidative stress A state in which ROS exceed antioxidant and repair capacity, disrupting cellular function and potentially causing cellular and molecular damage

The first enzyme, glutamatecysteine ligase (GCL) formerly called -glutamylcysteine synthase (GCS) is the rate-limiting enzyme

It is essential for efficient TGF-1/ALK1 pathway but indirectly blocks TGF-1/ALK5 pathway (Lebrin et al., 2004)

Gaps in the global regulatory frameworks for the use of artificial intelligence (AI) in the healthcare services sector and key recommendations

A 2017 review published in the International Journal of Molecular Sciences has found that nattokinase may be a beneficial antithrombotic agent to reduce the risk of cardiovascular disease ( 47 )