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For instance, ovariectomized rodents developed mechanical and thermal hyperalgesia, a state that was reversible upon estrogen supplementation [486, 487]

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however, any break in this protective layer allows wounds to become susceptible to colonization by pathogens (305)

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NADPH is the primary electron source for the GSR reaction as well as for many other reductase reactions, and maintaining its levels is extremely important for redox homeostasis and its support of many anabolic reactions, such as the reductive conversion of ribonucleotides to deoxyribonucleotides and lipogenesis [63]