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Indeed, other mechanisms contribute to tolerance such as activation of anti-opioid systems (NPFF, NMDA) (Ueda and Ueda, 2009) but they are beyond the scope of this review

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The hormonal shifts of perimenopause and menopause frequently trigger or worsen depression and anxiety, even in women with no prior psychiatric history

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Le et al., 2004

This mechanism is complementary to but distinct from the angiogenic properties of BPC-157 , which operates through different vascular growth factor pathways