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Krause D, Matz J, Weidinger E, Wagner J, Wildenauer A, Obermeier M et al (2010)

WEE1 inhibitors WEE1 is a vital target in the HRR pathway, and WEE1 inhibitors have been widely evaluated in combination with chemotherapeutic agents or PARPis in many ongoing clinical trials

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Clarifying the core mechanisms and key influencing factors of the contradictory conclusions on the regulatory effects of mitophagy is not only of great significance for in-depth understanding of the role of mitophagy in the occurrence and development of related diseases, but also provides important theoretical support for subsequent disease prevention and treatment strategies targeting mitophagy

116 Mitochondria and inflammation Inflammation is a defense response to the stimulation of inflammatory factors, which usually occurs with pathological changes such as cell necrosis and inflammatory cell infiltration